您的瀏覽器不支援 JavaScript喔，請開啟 Javascript 功能。
跳到主要內容
:::
Tamkang University
Tamkang University Chueh-Sheng Memorial Library
Sitemap
Login
繁體中文
X
About
About the DILS / Our Mission / Facility
Goals
Career Prospects
Future Prospects
Faculty
Full-Time Faculty
Adjunct Faculty
Professor Emeritus
Retired Faculty
Administration Staff
Admissions
International Students
Student Life
Programs
Undergraduate Program
University Department
Flexible Educational
Graduate Programs
Graduate Program
E-Learning Executive Program
Research
Journal of Educational Media & Library Sciences
Dissertation
Careers
Forms
Curriculum Section
Registrar Section(Student Affairs)
Registrar Section(Grade Affairs)
General Affairs
Freshman
jouniorhigh
Home
Faculty
Adjunct Faculty
:::
Full-Time Faculty
Adjunct Faculty
Professor Emeritus
Retired Faculty
Administration Staff
Title
Effects of SGLT2 inhibitors on stroke and its subtypes in patients with type 2 diabetes: a systematic review and meta-analysis
Year
109
Semester
2
Publish Date
2021/07/28
Journal Name
Effects of SGLT2 inhibitors on stroke and its subtypes in patients with type 2 diabetes: a systematic review and meta-analysis
Journal Name Other
All Author
Unit
Publisher
Volume
Scientific Reports 11(1), 15364
Summary
Sodium-glucose cotransporter 2 (SGLT2) inhibitors have shown impressive effects in reducing major vascular events in several randomized controlled trials (RCTs). The purpose of this study was to perform a meta-analysis to evaluate the effect of SGLT2 inhibitors on the risk of stroke and its subtypes. All data from prospective RCTs up to 20 October 2020 involving SGLT2 inhibitors that reported stroke events as the primary endpoint or safety in subjects with type 2 diabetes were subjected to meta-analysis. Five eligible RCTs (EMPA-REG, CANVAS, DECLARE-TIMI 58, CREDENCE and VERTIS CV) involving 46,969 participants were included. Pooled analysis of the RCTs showed no significant effect of SGLT2 inhibitors on total stroke [risk ratio (RR) = 0.95; 95% confidence interval (CI) 0.79–1.13, P = 0.585]. Subgroup analysis indicated that SGLT2 inhibitors had no significant effect against fatal stroke, non-fatal stroke, ischemic stroke or transient ischemic attack. When only hemorrhagic stroke was included, SGLT2 inhibitors were associated with a significant 50% reduction compared with placebo (RR = 0.49, 95% CI 0.30–0.82, P = 0.007). This meta-analysis shows that SGLT2 inhibitors have a neutral effect on the risk of stroke and its subtypes but a potential protective effect against hemorrhagic stroke.
Keyword
Stroke;Type 2 diabetes
Use Lang
English
ISSN
2045-2322
Journalnature
國外
Included in
,SCI
UniversityCooperation
CorrespondingAuthor
Reviewsystem
否
Country
英國
Open Call for Papers
PublicationStyle
電子版